To investigate the effect of macrophage-specific ORP2 overexpression on hyperlipidemia and atherosclerosis, we crossed hORP2MOE mice with ApoE−/− mice, which are prone to hypercholesterolemia and atherosclerosis, to generate hORP2MOE/ApoE−/− mice. Here, OSBPL2 is linked to familial hypercholesterolemia.