Since ORP2 facilitates cholesterol transport to the plasma membrane, and previous research in A431 cells has shown that ORP2 mediates the flux of LDL-derived cholesterol from late endosomes/lysosomes (LE/Lys) to recycling endosomes (13, 15), ORP2 might play a role in cholesterol deposition within atherosclerotic lesions. Here, OSBPL2 is linked to Atherosclerotic lesion.