During the rest phase (CT30 and CT34), ECM-receptor interaction (e.g., Tnxb, Col4a1, and Col6a1) was the most enriched pathway among genes downregulated in WT KPC mice, while hypertrophic cardiomyopathy (e.g., Des, Tnnc1, and Myl3) was the most enriched pathway among upregulated genes. The gene discussed is DES; the disease is hypertrophic cardiomyopathy.