To determine the translational relevance of these findings, we leveraged our previously published transcriptomic dataset obtained from skeletal muscles of patients with pancreatic ductal adenocarcinoma (PDAC).26 Core clock genes were extracted and correlated with our published skeletal-muscle index (SMI) data obtained from computed tomography scans of the same patients.29 We found statistically significant negative correlations between SMI and expression levels of the clock transcriptional repressors PER1, PER2, and NFIL3 (Figure 6A). Here, CLOCK is linked to pancreatic ductal adenocarcinoma.