Interestingly, following activity onset (CT38), pathways established to be involved in cancer-induced muscle wasting, including JAK-STAT, tumor necrosis factor (TNF), and FoxO signaling pathways, were enriched from genes increased in KPC mice (e.g., Jak3, Osmr, Nfkbia, Bcl3, Gadd45g, and Cebpb). The gene discussed is BCL3; the disease is cancer.