In this regard, consistent sleep, feeding, and physical activity patterns have been shown to reset dysregulated circadian rhythms and improve clock function in skeletal muscle and other tissues.35 Mechanistically, these lifestyle modifications are thought to improve clock function by enhancing the rhythmic expression of transcription factors, cofactors, and genes that regulate metabolism,36,37 and their study in the context of skeletal-muscle clock disruption in tumor-bearing hosts certainly warrants investigation. Here, CLOCK is linked to neoplasm.