KEGG analysis of genes increased in WT KPC mice compared to cancer-free controls during the active phase (CT18 and CT22) (Figure 4B), identified an enrichment of genes annotating to circadian rhythm, and, specifically, genes encoding the negative limb of the circadian mechanism, including Per1, Nr1d1, and Bhlhe40 (Figure 4C). Here, NR1D1 is linked to cancer.