CLOCK and cancer: In line with this, analysis of RNA-seq data collected from skeletal muscles of cancer-free mice with inducible skeletal-muscle-specific FOXP1 overexpression (FoxP1iSkmOE) revealed that FOXP1 overexpression is sufficient to upregulate transcriptional repressors of the clock (Per1, Cry2, and Bhlhe41) and repress clock activators (Bmal1 and Clock) (Figure 5A).