During the rest phase (CT30 and CT34), ECM-receptor interaction (e.g., Tnxb, Col4a1, and Col6a1) was the most enriched pathway among genes downregulated in WT KPC mice, while hypertrophic cardiomyopathy (e.g., Des, Tnnc1, and Myl3) was the most enriched pathway among upregulated genes. This evidence concerns the gene COL6A1 and hypertrophic cardiomyopathy.