Interestingly, following activity onset (CT38), pathways established to be involved in cancer-induced muscle wasting, including JAK-STAT, tumor necrosis factor (TNF), and FoxO signaling pathways, were enriched from genes increased in KPC mice (e.g., Jak3, Osmr, Nfkbia, Bcl3, Gadd45g, and Cebpb). This evidence concerns the gene JAK3 and cancer.