These 104 REGs included 37 direct FOXP1 targets identified via ChIP-seq, including genes involved in carbohydrate metabolism (e.g., Ppp1r3c and Glul), lipid metabolism (e.g., Pltp and Rora), and mitochondrial regulation (e.g., Ubc and Hspa1b) (Figure 3E; Table S2), supporting FOXP1 as a key player in the transcriptional disruptions of these metabolic networks in muscle during cancer. This evidence concerns the gene RORA and cancer.