Previous observations suggest that RES activates SIRT1 in the biological tissue of individuals with obesity and HFD rodents (Pfluger et al., 2008; Price et al., 2012; Timmers et al., 2011), which in turn protects against HFD‐induced metabolic damage through preserved lipid and energy metabolism and reduced inflammation (Pfluger et al., 2008). The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.