SIRT1 and obesity due to melanocortin 4 receptor deficiency: In humans living with overweight and obesity, RES supplementation has been demonstrated to reduce markers of inflammation, activate AMPK, and increase SIRT1 and peroxisome proliferator‐activated receptor gamma coactivator 1α protein levels, leading to SkM mitochondrial biogenesis, enhanced mitochondrial function, and reduced intramyocellular lipids, adipocyte size and whole body adiposity (De Ligt et al., 2018; Konings et al., 2014; Méndez‐del Villar et al., 2014; Polanen et al., 2021; Timmers et al., 2011).