In particular, obesity causes low grade chronic inflammation (Erskine et al., 2017) and, in combination with muscular lipid accumulation (Messa et al., 2020), this can result in reduced silent information regulator 2 mammalian ortholog (SIRT1) and 5′‐adenosine monophosphate‐activated protein kinase (AMPK) activity (Tallis et al., 2017, 2018), as well as impaired SkM protein synthesis (Akhmedov & Berdeaux, 2013), mitochondrial function (Heo et al., 2017) and excitation contraction coupling (Eshima et al., 2020). The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.