Previous observations suggest that RES activates SIRT1 in the biological tissue of individuals with obesity and HFD rodents (Pfluger et al., 2008; Price et al., 2012; Timmers et al., 2011), which in turn protects against HFD‐induced metabolic damage through preserved lipid and energy metabolism and reduced inflammation (Pfluger et al., 2008). This evidence concerns the gene SIRT1 and Obesity.