When SIRT1 and closely associated molecular pathways (e.g. AMPK and nuclear factor kappa B) are inhibited through obesity, excessive fat deposition can occur through impaired lipid metabolism and increased chronic low‐grade inflammation and oxidative stress (Fu et al., 2013; Lyons & Roche, 2018; Pardo & Boriek, 2020; Steinberg et al., 2006; Tallis et al., 2018), comprising factors that mediate obesity‐induced SkM dysfunction. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.