Mice with a cardiac‐specific BDH1 KO also demonstrated worsened cardiovascular outcomes (e.g., decreased LVEF) following TAC‐induced heart failure, whereas a 2‐week continuous infusion of βOHB into the right ventricle prevented the decline of LVEF and cardiac output in a tachypacing model of heart failure in canines (Horton et al., 2019). Here, BDH1 is linked to heart failure.