SIRT1 and myocardial infarction: showed that overexpression of miR‐29b results in HCs loss and mitochondrial dysfunction through downregulation of the SIRT1/PGC‐1α signaling pathway with aging.[145] Notably, the rs1894720 polymorphism in the myocardial infarction‐associated transcript (MIAT) gene has been shown to increase susceptibility to ARHL by altering the miR‐29b/SIRT1/PGC‐1α signaling pathway.[146]