Research has indicated a significant decline in SIRT1 expression in the aging mouse cochlea and auditory cortex, a deficiency that is linked to the expression of miR‐34a in these regions during aging.[142, 143] Furthermore, studies have demonstrated that either overexpression of SIRT1 or knockdown of miR‐34a mitigates age‐related cochlear HCs loss and hearing loss in C57BL/6 mice.[144] Similarly, Xue et al. This evidence concerns the gene SIRT1 and hearing loss disorder.