In scRNA‐seq studies of the mouse cochlea, we observed a consistent upregulation of the Sncb gene in SGNs with aging.[45] The Sncb gene encodes a member of a small family of proteins that inhibit phospholipase D2, which is abundant in neurofibrillary lesions in Alzheimer's disease and has been implicated in triggering oxidative stress and inflammatory responses in the aged retina.[127] These findings suggest that as SGNs experience increased oxidative stress and inflammatory responses due to aging, SGNs injury may exacerbate ARHL. The gene discussed is SNCB; the disease is early-onset autosomal dominant Alzheimer disease.