Microglial calcium signaling, a critical surrogate indicator of phagocytic activity, is strongly engaged during epilepsy development and fluctuates with intracellular activities.[56, 59, 60] To substantiate the involvement of MS4A4A in microglial phagocytosis during epilepsy pathogenesis, we generated P2yr12;Ai95 mice to specifically track calcium flux within microglia. This evidence concerns the gene MS4A4A and epilepsy.