The conserved α‐methylene‐γ‐lactone moiety among NLRP3‐inhibiting phytochemicals suggested a structure‐activity relationship, motivating systematic evaluation of sesquiterpene lactone libraries.[35]Inula helianthus aquatica, known to enrich such a structure, was identified as the source of major component in TCM decoctions used to treat respiratory disorders such as bronchitis and asthma.[23] In vivo models of ARDS demonstrated that three sesquiterpene lactones found in the plant, bigelovin, ergolide, and 8‐epi‐helenalin, showed potent preventive and therapeutic effects. Here, NLRP3 is linked to respiratory system disorder.