The conserved α‐methylene‐γ‐lactone moiety among NLRP3‐inhibiting phytochemicals suggested a structure‐activity relationship, motivating systematic evaluation of sesquiterpene lactone libraries.[35]Inula helianthus aquatica, known to enrich such a structure, was identified as the source of major component in TCM decoctions used to treat respiratory disorders such as bronchitis and asthma.[23] In vivo models of ARDS demonstrated that three sesquiterpene lactones found in the plant, bigelovin, ergolide, and 8‐epi‐helenalin, showed potent preventive and therapeutic effects. The gene discussed is NLRP3; the disease is asthma.