Furthermore, we found that the flavonoid lonicerin acts as an EZH2 inhibitor, thereby alleviating excessive inflammation in the ulcerative colitis model.[19] During our search for natural products targeting the NLRP3 inflammasome and its mediators, we identified sesquiterpene bigelovin as a covalent binder that blocks RACK1‐mediated NLRP3 oligomerization, using an isoTOP‐ABPP chemoproteomic approach.[20] Here, we report the discovery of a RACK1 inhibitor that exerts NLRP3 inflammasome antagonistic activity in vitro and in vivo. The gene discussed is RACK1; the disease is ulcerative colitis.