Mechanistically, sesquiterpene lactone bigelovin covalently binds to a cysteine residue of RACK1 and blocks NLRP3 oligomerization (active conformation), inhibiting the assembly of NLRP3 inflammasome, caspase‐1 activation, and IL‐1β production, which ultimately reduces ARDS severity. Here, IL1B is linked to acute respiratory distress syndrome.