A study integrating WGS, scRNA‐seq, ATAC‐seq, and TCR‐seq revealed that CD16+ macrophages within the TME of multiple myeloma patients treated with CD14+ CAR‐T cells exhibited an exhausted phenotype.[128] Another study demonstrated that monocyte‐derived macrophages tend to adopt a pro‐tumor phenotype, which serves as a key driver of tumor relapse.[129] However, conventional and single‐cell sequencing techniques disrupt the spatial architecture of cells during sample processing, limiting investigations into the spatial heterogeneity of the TME. This evidence concerns the gene CD14 and neoplasm.