These receptors include heparan sulfate proteoglycans (HSPGs), integrins (such as αVβ3 and αVβ5), and other receptors; (2) transport and maintenance of viral DNA: After entering host cells, the viral DNA is transported into the cell nucleus and maintained as a circular epigenetic structure known as an episome; (3) latent infection and lytic cycle: KSHV can establish latent infection within host cells, where only a few viral genes are expressed, which are enough to sustain viral replication and cell survival but not sufficient to trigger the immune system’s attention. This evidence concerns the gene CD44 and disease arising from reactivation of latent virus.