HBZ and adult T-cell leukemia/lymphoma: Other studies have shown that HTLV-1 not only drives T-cells towards aerobic glycolysis but also, through different mechanisms, activates the TAp73 promoter by its encoded HBZ RNA and HBZ protein, inducing the expression of MCT1 and MCT4, increasing lactate secretion, and inhibiting ATLL cell death [122].