Patients with higher ssGSEA-score for this signature also showed significantly poorer 5-year disease specific survival (Fig. 8Eii, S11 C); highlighting the possibility of exhibiting clinical relevance of our observed CAF-specific-TGFβ-ANGPT-Tie2-Src signaling axis-driven reprogramming of oral cancer cells. The gene discussed is TEK; the disease is lip and oral cavity carcinoma.