TEK and cancer: Interestingly, a very distinct subset of clusters (clusters 2,3,7,9,15–18) was comprised of cancer cells from TGF-CAF coculture (Table S4), depicting TGF-CAF induced transcriptional reprogramming of cancer cells, which was apparently absent when cancer cells were co-cultured with Tie2-inhibited TGF-CAF (Fig. 6F).