To get deeper understanding about the intricate interplay between different CAF-phenotypes and their influence on oral cancer cells, we performed single cell RNA sequencing (scRNAseq) for co-cultures of oral cancer cells with C1-CAF (UT-CAF) or TGFβ-induced CAF (TGF-CAF) or TGFβ-induced-Tie2-inhibited (TGF > > Tie2i-CAF), separately (Figure S4 A, B (i,ii,iii)). Here, TGFB1 is linked to lip and oral cavity carcinoma.