Of interest, it has been shown that tau filaments from Guamanian variants of amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS-PDC) adopt a similar conformational folding to that of CTE p-tau, most notably by the presence of the unknown nonproteinacious inclusion within the β-helix cavity [255]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.