MAPT and stroke disorder: As outlined in the most recent National Institutes of Neurological Disorders and Stroke (NINDS) and National Institute of Biomedical Imaging and Bioengineering (NBIB) consensus pathological criteria, CTE is defined by the unique presence of abnormally phosphorylated tau (p-tau) inclusions in neurons and astrocytes at the depths of the sulci and surrounding blood vessels [19].