The pathway is a known mediator of fibrosis and suppressor of vascular invasion via cancer-associated fibroblasts (CAFs), potentially providing this subgroup with a more immunoprotected microenvironment [5].CYP2B6, CYP1A2, and CYP3A4 were associated with the “Chemical carcinogenesis” pathway. This evidence concerns the gene CYP3A4 and cancer.