DNM1L and glaucoma: Several groups have shown that cells respond to alterations in the stiffness of their surrounding extracellular matrix (ECM) by increasing dynamin-related protein 1 (Drp1) mediated mitochondrial fission, with associated alterations in mitoROS.11,38,39 Electron microscopy of pressurized optical neural cells in the setting of glaucoma has shown mitochondrial morphodynamic changes, including fission, swelling, and cristae depletion.