NTRK2 and neoplasm: PCR amplification from patient cDNA across the duplicated region confirmed the presence of NTRK2 ITD and wild type (WT) NTRK2 transcript (Fig. 1c and Supplementary Fig. 2) and pan-TRK immunochemistry (IHC) confirmed high-intensity extranuclear staining in the tumor (Fig. 1d), compared to control staining (normal brain, Supplementary Fig. 3).