Additionally, TDO2 was significantly downregulated in IFN-γ-treated MDA-MB-231 cells (p = 0.0034), potentially reflecting a response to IFN-γ-induced hypoxia, which has been previously shown to downregulate TDO2 expression in glioblastoma cell lines at the protein level using WB43. The gene discussed is IFNG; the disease is glioblastoma.