Abnormal laboratory data registered as AE in the Temcell combination group were iron-deficiency anaemia, low albuminemia, hypokalemia, hyperglycemia and hypoglycemia (n = 1, respectively), while those in the hypothermia therapy-alone group were increased C-reactive protein (n = 2), iron-deficiency anemia, low albuminemia, hypokalemia, hyperuricemia, increased plasma alkaline phosphatase, hyperbilirubinemia (n = 1, respectively). This evidence concerns the gene CRP and anemia.