USP6 and nodular fasciitis: In nodular fasciitis, chromosomal translocations cause overexpression of USP6, which activates the Wnt/β-catenin pathway [51].To further determine the role of Wnt signaling in USP6-mediated tumor growth, they tested USP6/NIH 3T3 cells with DKK1, a secreted protein that inhibits Fzd receptor activation.