Given the evidence of a high frequency of A*02:01-restricted ILD-specific T cells being detected amongst the HLA-A*02:01+ participants, we analysed the frequency, phenotype, and differentiation status of memory MPXV-specific CD8+ T cell using the HLA-A*02:01-ILD tetramer in both convalescent samples and samples 28 after a second vaccination. The gene discussed is HLA-A; the disease is interstitial lung disease.