Hur et al. reported that IFITM3 expression increases with age and contributes to elevated γ-secretase activity and Aβ production in Alzheimer’s disease [45], and Wu et al. implicated the cGAS-STING-IFITM3 axis in Aβ-induced neuroinflammation in microglia [46]. Here, CGAS is linked to early-onset autosomal dominant Alzheimer disease.