CRP and depressive disorder: That the association of anxiety with CRP is weaker when compared to depression and significantly attenuated following adjustments for covariates may be indicative of, for example, the relatively high levels of comorbid depression and anxiety (i.e., higher CRP in anxiety is confined primarily to anxious individuals with depression) or that the proportion of individuals with inflammatory anxiety is even smaller than the ~25% of depressed individuals with an inflammatory phenotype [108].