CRP and agoraphobia: The MR analysis may be indicative of a potentially causal role of CRP on the likelihood of meeting criteria for an anxiety disorder (which covers a broad range of anxiety-related conditions including panic disorder, social phobia, agoraphobia, GAD); however, it should be noted the p value (p = 0.054) did not meet a threshold for statistical significance and therefore is in particular need of replication in a adequately powered research study.