We added six actors having a role in extracellular matrix (ECM) remodeling, thus promoting angiogenesis, tumor cell migration, and metastatic spreading: two members of the matrix metalloprotease family (MMP2 and MMP9),[52] the copper‐dependent amine oxidase LOX,[53] the proteoglycan biglycan,[54] Slit2, a secreted protein with potential of cancer cell guidance,[55] and Jagged1, a notch ligand.[56]. The gene discussed is BGN; the disease is neoplasm.