AD involves the progressive accumulation of Aß into oligomers and plaques and intra-neuronal tau aggregates, forming neurofibrillary tangles that lead to neuronal synaptic dysfunction and neuronal death (Bachiller et al., 2018; Jack Jr et al., 2019; Sebastian-Serrano et al., 2018; Terry et al., 1994). The gene discussed is MAPT; the disease is Alzheimer disease.