PLK1 and neoplasm: In support of this observation, analysis of TCGA data revealed a positive correlation between PLK1 and IGF2BP2 expression (Spearman’s r ≥ 0.3) across multiple tumor types (Figure 3B), suggesting that IGF2BP2 modulates PLK1 levels and is thus preferentially essential in cancer cells relying on PLK1 overactivation.