In particular, ZMYND8 expression was notably lower in MM samples than in monoclonal gammopathy of undetermined significance (MGUS) samples (Figure S1F, Supporting Information), and the ROC curve indicated that ZMYND8 is a robust diagnostic biomarker for discriminating between MGUS and MM (Figure S1G (Supporting Information), AUC = 0.872). Here, ZMYND8 is linked to monoclonal gammopathy.