ZMYND8 and Miyoshi myopathy: proposed that the H3K36me2 reader protein HRP2 functions as a suppressor of BTZ resistance and inhibits the survival of MM cells by demethylating H3K27me3 in the context of t(4;14) abnormalities.[40] Here, we identified and confirmed a new H3K36me2 reader, ZMYND8, that activates CEBPE expression at the promoter level by recognizing H3K36me2 in MM cells.