ZMYND8 and colorectal cancer: Altered expression of ZMYND8 is strongly associated with oncogenesis and tumor development.[14] Elevated ZMYND8 expression has protumorigenic effects on colorectal cancer, hepatocellular carcinoma, and bladder cancer.[21, 22, 24, 26] Conversely, low ZMYND8 expression promotes tumor malignancy in prostate cancer and nasopharyngeal carcinoma.[17, 19] Thus, the function of ZMYND8 in different tumors remains controversial.