TNFRSF1B and Peripheral demyelination: Therefore, as activated astrocytes and microglia play a crucial role in facilitating remyelination [24] and express TNFR2 in the demyelinated CC [35, 36], we next assessed if the TNFR2 agonist affected the sustained neuroinflammatory response during the remyelination process following cuprizone-induced demyelination.