A significant positive correlation was observed between IL36RN expression and CD8+ T cell infiltration in both the cancer nest (R = 0.23, p < 0.05; Figure 4F) and stromal compartment (R = 0.29, p < 0.05; Figure 4G), suggesting that IL36RN may influence CD8+ T cell dynamics in the TME and could serve as a potential therapeutic target in GC. The gene discussed is CD8A; the disease is gastric cancer.