Combined with the previous finding that lncRNA‐GPHN targets miR‐320 and reduces its expression, we propose the lncRNA‐GPHN/miR‐320/YWHAH regulatory axis: lncRNA‐GPHN negatively regulates miR‐320 to promote the expression of the apoptosis‐related protein YWHAH, reducing neuronal excitability and apoptosis, ultimately alleviating epileptic seizures. Here, YWHAH is linked to Seizure.