ACHE and Alzheimer disease: A deficit in cholinergic neurotransmission is prevalent in AD (Cummings et al. 2024), and acetylcholinesterase (AChE) inhibitors such as donepezil, rivastigmine, and galantamine are widely prescribed as cognitive enhancers to augment cholinergic signaling and improve cognitive performance in AD patients (Marucci et al. 2021).