The phylogenetic tree segregated initially into two distinct nodes, and it is notable that the only peptidase identified as significantly altered in FD from the Shanahan et al., and Shah et al. dataset, Xaa-Pro dipeptidase (K01271), is present on a separate node and thus most distantly related to the significantly altered peptidases in CeD patients. Here, LAP3 is linked to cranioectodermal dysplasia.