However, the mechanism of circ-RPPH1/EIF4 A3/regulating E-cadherin expression needs further study.The shortcomings of this study, Sample Size and Clinical Correlations: The lack of association between circ-RPPH1 and TNM stage/lymph node metastasis may reflect insufficient statistical power. Here, RPPH1 is linked to metastatic malignant neoplasm in the lymph nodes.