EIF3A and pulmonary arterial hypertension: To test the expression of eIF3 in the lung tissues of PAH rats treated with AAV1-shRNA-NC and AAV1-shRNA-eIF3a, we performed WB experiments, and the results are shown in Fig. 3B. The expression of eIF3a was significantly greater in the pulmonary tissues of PAH rats treated with AAV 1-shRNA-NC than in those of the control group, whereas eIF3a was significantly lower in AAV-shRNA-eIF3a-treated PAH rats than in those of the MCT group.