EIF3A and pulmonary arterial hypertension: Notably, we found that the high expression of collagen I and collagen III, the main components of the extracellular matrix in the lung tissue of pulmonary hypertension rats, was clearly reversed by the absence of eIF3a, indicating that the knockdown of eIF3a inhibited extracellular matrix deposition in the lung tissues of MCT-induced pulmonary hypertension rats.