PAK1 and early-onset autosomal dominant Alzheimer disease: Among these genes are PTEN, NRG1, CDK5, GRN, EPHA4, PAK1, MDB5, and NR4 A2 that are associated with various NDDs in humans, including schizophrenia [61], Parkinson disease [62], intellectual developmental disorder [63, 64], Alzheimer disease [60, 65], and autism spectrum disorder [64, 66, 67].