At these cut-off value, EPAC1 predicted the probability of CAD presence with a sensitivity of 51.1% and a specificity of 81.2% (Table 3), and predicted the probability of severe CAD (SIS > 4) with a sensitivity of 69.6% and a specificity of 79.4% (Table 4). Here, RAPGEF3 is linked to coronary artery disorder.