The performance of EPAC1 was superior to that of hs-CRP and hs-TnT in predicting CAD severity measured by SIS > 4 (AUC for EPAC1 = 0.814 vs AUC for hs-TnT = 0.723 and AUC for hs-CRP = 0.576) (Table 4). This evidence concerns the gene RAPGEF3 and coronary artery disorder.