Analysis of CD8+ PD-1+ CD107a+ TCM cells from activated PBMC-cancer cell co-cultures showed that cells expressing PD-L1WT resulted in lower levels of CD107a+ T-cells (5.5% ± 2.4%) compared to positive control T-cells activated without tumor cell exposure (8.7% ± 5.2%). The gene discussed is LAMP1; the disease is cancer.