Furthermore, intravenous injection of CD8+ T cells from different groups followed by tumor excision after 24 h for ex vivo measurements revealed that the sh-NCL-2 and sh-NCL-3 groups had the highest accumulation of CD8+ T cells, indicating that silencing NCL significantly enhanced the infiltrative capacity of CD8+ T cells in the tumor microenvironment (Fig. 4K-L). This evidence concerns the gene CD8A and neoplasm.