TXNIP and neoplasm: Subsequently, we intrathoracically injected LA795 or CMT64 cells into nude mice to establish an orthotopic tumor model, followed by intratumoral or intravenous injection of CD8+ T cells into the tumor-bearing mice, divided into groups as oe-NC + oe-NC + oe-NC, oe-NCL + oe-NC + oe-NC, oe-NCL + oe-MYC + oe-NC, and oe-NCL + oe-MYC + oe-TXNIP (Fig. 8A).