OTOF and hearing loss disorder: OTOF variants have been identified as the cause of hearing impairment in approximately 5% of Turkish patients (Duman et al. 2011), 3% of Pakistani patients (Choi et al. 2009; Richard et al. 2019), 2.4% of European-American patients (Sloan-Heggen et al. 2016), 1.9% of French patients (Baux et al. 2017), and 1.7% of Japanese patients (Iwasa et al. 2019) who were not pre-selected for ANSD.