DLX6 and ectodermal dysplasia syndrome: Notably, a case report of severe X-linked hypohidrotic ectodermal dysplasia with tooth agenesis highlighted the loss of XIST on the X chromosome, leading to disruption of the EDA gene.53 Furthermore, we demonstrated that the CDP-specific DLX6-AS1 enhances odontoblastic differentiation of hTGMCs and hDPSCs.