For instance, a combination of anti-VEGFR2 and anti-PD-L1 antibodies induced formation of high endothelial venules that facilitated enhanced infiltration and activity of cytotoxic lymphocytes and tumour cell death in RT2-PNET (Rip1-Tag2) pancreatic neuroendocrine cancer and PyMT (polyoma middle T oncoprotein) breast cancer [95]. This evidence concerns the gene CD274 and breast cancer.