Further, to investigate the CILP1 expression characteristics in more skin fibrosis diseases other than hypertrophic scar, immunohistochemical staining was applied, which suggested the major distribution of CILP1 in dermis, and the level of CILP1 was higher in human HS and keloid scar (KS) tissues compared to human NS tissues (Fig. 1E, F). Here, CILP is linked to keloid.