Heatmap of CML patients from RNA-Seq showed that some mitochondrial genes were changed between wildtype and T315I, such as succinate dehydrogenase A (SDHA), superoxide dismutase (SOD) and ubiquinol-cytochrome c reductase core protein (UQCRC) (Fig. 2i). The gene discussed is SOD1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.