CRP and plasma cell leukemia: Factors that were associated with significantly worse OS in multivariable analysis in the entire cohort included ECOG ≥ 2 (HR 1.92, p = 0.0101), baseline CRP ≥ upper quartile (HR 2.58, p = 0.0002), baseline platelets <50 × 109/L (HR 2.54, p = 0.0005), baseline absolute lymphocyte count <0.5 × 109/L (HR 1.97, p = 0.0062) and presence of plasma cell leukemia prior to start of Tec (HR 5.24, p = 0.0320).