A total of four (clusters 1, 2, 4, 5; supplementary fig. 8) new macrophage and DC subsets significantly enrich the microvascular interface after AKI (Fig. 6e), including CCR2+CD300A+CD163+ monocyte-derived, M2-polarized macrophages (cluster 2; 5-fold increase; Fig. 6f). The gene discussed is CCR2; the disease is acute kidney injury.