For our assays, we collected 10 tumors (3 LGG IDH1/2mut, 5 HGG tumors, and 2 HGG IDH1/2 mut) and performed KAT5 activity and protein synthesis assays (30 min treatment with O-propargyl-puromycin (OPP)) in match cohorts of tumor cells (Fig. 7d). Here, KAT5 is linked to neoplasm.