SOX8 and cancer: For KAT5off tumors, 218 superenhancer regions were associated with many of the OPC and RG/Ac genes highlighted above, including BCAN, C1ORF61, GNG7, SMOC1, and SOX8, as well others including angiotensinogen (AGT), a biomarker for bevacizumab response in GBM, CSPG5, a marker of OPC cells, DBI, associated with quiescent cancer cells, and GFAP, a key astrocytic marker found in the RG/Ac cluster (Supplementary Fig. 12h).