KAT5 target genes also include many transcription factors essential for GSC-0827 outgrowth which extend beyond common essential genes: E2F3 (cell cycle entry)54, MYC (cell cycle/growth)55, NFE2L2 (redox homeostasis)56, POU3F2 (GBM stem-ness)57, and TCF7L2 (Wnt pathway/ G1/S transition)58(Fig. 5c). The gene discussed is POU3F2; the disease is glioblastoma.