We observed significantly higher expression in grade 2 and 3 IDH1/2 wt gliomas compared to grade 4 IDH1/2 wt tumors, and also higher expression in IDH1/2 mutant grade 2 and 3 gliomas compared to IDH1/2 wt grade 2 and 3 tumors (Supplementary Fig. 14). Here, IDH1 is linked to central nervous system cancer.