Analyses in cells from CdLS patients and mouse models of NIPBL haploinsufficiency reveal altered gene expression but not cohesion defects (Liu et al. 2009; Remeseiro et al. 2013; Boudaoud et al. 2017; Newkirk et al. 2017; Garcia et al. 2021). This evidence concerns the gene NIPBL and Cornelia de Lange syndrome.