The HCAR1 agonist 3,5-DHBA failed to save the axonal loss in hypoglycemia, but slices from HCAR1 KO displayed more loss relative to WT (%NF200/Control: WTHG_DHBA 49 ± 28, KOHG_DHBA 22 ± 11, pHG_DHBAWT-KOp < 0.001; Fig. 3B,D). Here, HCAR1 is linked to Hypoglycemia.