HCAR1 and Hypoglycemia: While lactate could completely rescue myelination in hypoglycemia in slices from WT mice, the HCAR1 KO slices failed to fully restore myelination (%MBP/Control: WTHG_Lactate 89 ± 22, KOHG_Lactate 61 ± 28, pHG_LactateWT-KOp < 0.001; Fig. 3C,E).