It is known that intravitreal injection of ET-1 in rodent models causes RGC degeneration and that ET-1 levels are a factor in glaucoma development (Bursell et al, 1995; Chauhan et al, 2004; Masuzawa et al, 2006; Lau et al, 2006; Wang et al, 2008; Nagata et al, 2014; Lommatzsch et al, 2022). Here, EDN1 is linked to glaucoma.