ZBP1 and neoplasm: In line with that, genetically engineered tumors deficient in these nucleic acid receptor systems phenocopied tumor resistance to ICI with MLKL−/− tumors.24 26 Activation of other nucleic acid sensors such as Z-DNA binding protein 1 (ZBP1) (potentially upon detection of endogenous viral elements) can similarly induce necroptosis and immunosurveillance in murine tumors.6 28 Genotoxic stress seems to enhance these effects through sensing of aberrantly located self RNA and DNA by intrinsic nucleic acid receptors.