In the miRNA–mRNA network, miR-548x-3p showed a targeted regulatory relationship with CCNA2. Previous research found that miR-548x-3p was overexpressed in circulating monocytes of women with osteoporosis, which could inhibit the proliferation, migration, and invasion of SaOS2 and U2OS cells; the mechanism of miR-548x-3p as a modulator in bone remodeling might be related to the inhibition of MAF BZIP transcription factor B (MAFB) and signal transducer and activator of transcription 1 (STAT1) (41). The gene discussed is MAFB; the disease is osteoporosis.