TF and endometrial cancer: In the TF–mRNA network for this study, TP53 was a transcriptional regulator upstream of CCNA2. TP53-WT endometrial cancer with high CCNA2 expression had a targeted transcriptomic profile similar to that of TP53-mutant type endometrial cancer, suggesting that CCNA2 was a seminal determinant for TP53-WT and TP53-mutant type endometrial cancer (35).