TIMP1 and pachyonychia congenita: Here, we identified tissue inhibitor of metalloproteinases-1 (TIMP-1), a glycoprotein with glycosylation sites at N30 and N78 harboring both canonical antiproteolytic and noncanonical cytokine-like activity, as one of the most upregulated secreted glycoproteins circulating in the blood of pancreatic cancer (PC) patients.