Since no differences were found between normal myometrium and leiomyoma with respect to the genomic distribution of MED12 and CDK8 in relation to H3K27 acetylation status (Fig. S3), we hypothesized that the specific local chromatin environment in myometrium and leiomyoma might contribute to the association of MED12 and CDK8 with chromatin. This evidence concerns the gene MED12 and leiomyoma.